Cisplatin resistance mechanism

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August undefined, 2024

WebDDP has gradually become the standard chemotherapy method for chronic lung adenocarcinoma and postoperative grade II and III lung adenocarcinoma. 8 Although lung adenocarcinoma reacts well in the initial stage of standard cisplatin chemotherapy, significant DDP resistance develops before chemotherapy (primary resistance) or … WebApr 22, 2024 · Resistance to cisplatin, a platinum-based drug used as first-line chemotherapy treatment is a prominent example that has been extensively studied in …

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin Resistance ...

WebApr 22, 2024 · In cisplatin-resistant cells, mitochondria are more fragmented and closer to the ER. ... BNIP3-driven mitophagy is involved in cisplatin resistance mechanism. WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, … glenwood springs colorado resort

Cisplatin-resistant triple-negative breast cancer subtypes: multiple ...

WebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase … WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … WebSep 9, 2014 · Another resistance mechanism to cisplatin and oxaliplatin is increased glutathione concentration, which inactivates platinum compounds before DNA damage occurs. Metallothioneins are small cysteine-rich proteins involved in metal detoxification and may play a role as stress proteins in response to platinum complexes. 76 Once inside … body shops in louisville ky

The Challenging Treatment of Cisplatin-Resistant Tumors: State …

Molecular mechanisms of cisplatin resistance - PubMed

WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist effects. ... In addition, more research is still needed to further clarify the potential mechanism by which USP14 regulates DDP resistance in both in vitro and in vivo models of NSCLC. WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased uptake or increased efflux; increased inactivation by intracellular proteins such as glutathione; increased repair of cisplatin adducts; increased ability to replicate past … body shops in madisonWebApr 13, 2024 · YTHDF1 interacts with the binding motif of GLS1 and increases glutamine uptake to enhance glutamine metabolism in cisplatin-resistant CRC cells. The inhibition of GLS1 leads to an increased sensitivity to cisplatin-induced cell death and YTHDF1 is also a potential target in overcoming resistant colon cancers . In gastric cancer, YTHDF2 … body shops in ludington mi

"WebFeb 25, 2024 · Autophagic flux in cisplatin-resistant ovarian cancer cells is caused by cisplatin. At present, the cytoprotective function of autophagy in cancer cells is considered a potential chemotherapy resistance mechanism. Most studies have suggested that targeting autophagy-related molecules may increase the chemosensitivity of cancer cells … " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin Resistance ...

WebJan 9, 2024 · Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway ... WebJun 15, 2024 · Based on the above reasons, this study mainly explored the molecular mechanism of DDP resistance in TNBC. We argue that the miR-133b-fibroblast growth factor receptor 1 (FGFR1) axis may mediate the tumor growth and DDP resistance of TNBC by regulating the Wnt-β-catenin pathway. miR-133b is related to the survival and …

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WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … WebCisplatin resistance arises through a multifactorial mechanism involving reduced drug uptake, increased drug inactivation, increased DNA damage repair, and inhibition of transmission of DNA damage recognition signals to the apoptotic pathway.

Web1 day ago · The resistance to cisplatin caused by MSH2 mutation can be partly rescued by proteasome inhibition (bortezomib), suggesting an adjuvant chemotherapeutic approach [39]. ... Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. ACS CHEM BIOL, 17 … WebApr 1, 2016 · Resistance to cisplatin occurs by the following molecular mechanisms: altered DNA repair, altered cellular accumulation of drug, and cytosolic inactivation of drug. The processes of resistance were studied in L1210 mouse leukemia cells and human ovarian cancer cells [7], [8], [9], [10].

WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased … WebMar 3, 2008 · Resistance to platinum chemotherapy is multifactorial ( 2 – 6 ). There are five recognized DNA repair pathways that protect cellular DNA from injury: nucleotide excision repair, mismatch repair (MMR), double-strand break …

WebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation.

WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting … body shops in lynnwood waWebOct 13, 2024 · An overview of the categories of platinum resistance mechanisms represented in the database is provided below. Regulation of drug entry, exit, accumulation, sequestration, and detoxification... body shops in madison alWebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the … glenwood springs colorado spaWebJul 26, 2024 · Galuzzi et al. classified the cisplatin resistance mechanisms into four categories: (i) pre-target resistance, preventing the binding of cisplatin to DNA by reduced cellular accumulation or enhanced binding to cytoplasmic components; (ii) on-target resistance, by tolerating or repairing cisplatin-DNA adducts; (iii) post-target resistance, … body shops in manassas vaWebJan 1, 2016 · Cisplatin is an alkylating agent capable of forming adducts with macromolecules, particularly with N7 atoms of purine nucleobases. This results in inter- and intra-strand DNA cross-links that bring induce cell cycle arrest mainly in the G 2 /M checkpoint ( Yuan et al., 2003 ). body shops in lynchburg vaWebCisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall, and Michael M. Gottesman David R. Sibley, ASSOCIATE EDITOR Author informationCopyright and License informationDisclaimer body shops in marshall mnWebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways … body shops in marianna fl