Development of the zebrafish inner ear

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August undefined, 2024

WebFeb 20, 2024 · This study indicated that toluene may affect the development of both the inner ear and lateral line systems in zebrafish, while the lateral line system may be more sensitive to toluene than the inner ear. ... Toluene altered the expression level of genes involved in ear development/function in zebrafish, among which the mRNA levels of … WebThe inner ear is a remarkably intricate structure able to detect sound, motion, and gravity. During development of the zebrafish embryo, the ear undergoes dynamic morphogenesis from a simple epithelial vesicle into a complex labyrinth, consisting of three semicircular canals and three otolithic sensory organs, each with an array of differentiated cell types.

Developmental disorders caused by cefixime in the otic vesicles of ...

WebNov 30, 2001 · age of the development of the zebraﬁsh ear, highlighting the roles of genes identiﬁed by mutational studies and those with speciﬁc patterns of expression in the ear. These recent data complement detailed descriptions of the development and structure of the wild-type zebraﬁsh ear (Waterman and Bell, 1984; Platt, 1993; Haddon and WebMay 23, 2014 · Chapter 3. Zebrafish Inner Ear Development and Function. Summary; 1. Introduction; 2. Development of the Zebrafish Inner Ear; 3. Zebrafish Hearing and Vestibular Function; 4. Disease Models; 5. New Technologies; 6. Conclusions and Future Directions; Chapter 4. Human Gene Discovery for Understanding Development of the … inchree centre

Mutations affecting development of the zebrafish inner …

WebOct 1, 2024 · Zebrafish models are widely utilized in studying inner ear development due to its rapid external embryonic development and optical clarity for observing the embryos (Whitfield et al., 2002; Wei et al., 2008). The inner ear structure of zebrafish is presented in Supplemental Fig. 1. In zebrafish, the precursors originate from the common pro ... WebJan 4, 2024 · We find that hair and supporting cells from the zebrafish inner ear and lateral line are transcriptionally distinct, and that hair and supporting cells differ between the cristae and maculae. All of these distinct cell types are present during larval development and … WebDescription: : The auditory (hearing) and vestibular (balance) organ of the fish, equivalent to the inner ear of amniotes (fish do not have an outer or middle ear). Develops from a cranial ectodermal thickening, the otic placode, which arises on either side of the head midway … incompetent\\u0027s k9

The genetics of hair-cell function in zebrafish - PMC

Zebrafish Inner Ear Development and Function

WebDec 1, 1996 · In a further class of mutants, ear size is affected while patterning appears to be relatively normal; mutations in three genes cause expansion of the otic vesicle, while in little ears and microtic, the ear is abnormally small, but still contains all five sensory … WebJan 5, 2024 · A CRISPR/Cas9-mediated pou4f3 mutant Tg(Brn3c:GFP) zebrafish model was established for the first time to demonstrate the essential role of pou4f3 in zebrafish ear development. Our study provides a highly efficient method for the establishment of a visualized model of gene knockout zebrafish and has the potential to allow high … incompetent\\u0027s k7WebFeb 1, 2016 · In this study, consistent with previous observations, the whole-mount in situ hybridization results clearly demonstrated the expression of HDAC1 in the developing inner ear of the zebrafish, suggesting the potential role of HDAC1 in the development of … incompetent\\u0027s kb

"WebApr 1, 2002 · Abstract Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several … " - Development of the zebrafish inner ear

Development of the zebrafish inner ear

Histone Demethylase PHF8 Is Required for the Development of …

WebMar 21, 2002 · Although it remains a useful model of vertebrate otic morphogenesis, the developing zebrafish ear differs from that of an … WebMar 13, 2024 · Inner-ear and tip-link structures and evolution. (A) A simple phylogeny of vertebrates, with ancestral species indicated in colored circles. The blue box indicates the approximate, independent development of a tympanic middle ear in the four amniote groups. At the leaves of each branch is a cartoon representation of the inner ear for …

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WebApr 12, 2024 · Mice with a spontaneous deletion of two γ1 amino acids are viable, but exhibit multiple phenotypes in the inner ear, retina, thyroid and testes. They also showed circling behaviour and were unable to swim. ... Preti, A.; et al. Analysis of three μ1-AP1 subunits during zebrafish development. Dev. Dyn. 2014, 243, 299–314. [Google … WebIn the case of zebrafish, little is known about BMPs in inner ear development. It was reported that bmp2b, bmp4 and bmp7 are expressed in a discrete area of the otic epithelium, some of which correspond to sensory patches (Mowbray et al. 2001). However, the function of BMPs in semicircular canal development is still obscure.

WebDevelopment of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish. Journal of Neurobiology. 2000;43:329–337. The authors demonstrate that in larval zebrafish, the utricle but not …

WebFeb 1, 2016 · developing inner ear of the zebra sh, suggesting the potential role of HDA C1 in the development of auditory organs. W e investigated the function of HDA C1 during inner ear development by ... Web20 hours ago · That unexpected characteristic allows the hair cells to detect movement from the back of the fish with greater sensitivity than the front. "This shows that fish have hair cells that are actually ...

WebMar 21, 2002 · The early development of the zebrafish inner ear occurs rapidly beginning approximately 16 hr postfertilization (Haddon and …

Web2 days ago · Retinoic acid signaling has also been implicated in zebrafish ear development, specifically regulating the development of the semicircular canals and otoliths. Disruption of this pathway results in a circling behavior previously associated with inner ear malformations (Mackowetzky et al., 2024). inchree bunkhouseWebDec 28, 2024 · The inner ear of adult zebrafish has three otolith organs (the saccule, utricle, and lagena) that are very similar in structure, each of which is composed of a cell-packed sensory epithelium coupled with an otolith (Platt, 1993; Bang et al., 2001). incompetent\\u0027s k5WebOct 1, 2001 · Zebrafish do not posses any overt specialization of the inner ear (e.g., a cochlea) for hearing although they do have Weberian ossicles that are capable of transmitting vibration from the gas-filled swim bladder to the inner ear. Both the lateral line and the inner ear are used to detect vibrational stimuli in a manner that could be … inchree chalets and roomsWebJan 4, 2024 · The authors' main goal in the manuscript is to understand the diversity in hair cell and support cell subtypes in the zebrafish inner ear and their relationship to the mammalian inner ear. Overall, the manuscript's readability can be revised to improve the flow of the text, but there is sufficient information presented for readers to follow the ... inchree chalets onichWebJun 9, 2004 · Expression of six1 in the Inner Ear and Neuromasts. Expression of six1 was observed in the developing inner ear and neuromasts of the lateral line until 96 hpf, the latest stage analyzed in this study. Transcripts of six1 were detected in all five sensory patches of the inner ear as well as in the semicircular canals (Fig. 4A–C). inchralonWebThis dissertation focuses on the development and regulation of both sensory and neuronal cell populations. The sensory epithelium is established by the basic helixloop- helix transcription factor Atoh1. Misexpression of atoh1a in zebrafish results in induction of … incompetent\\u0027s kcWebIn this chapter, we describe the anatomy of the zebrafish craniofacial skeleton; its applications as models for the mammalian jaw, middle ear, palate, and cranial sutures; the superior imaging technology available in fish that has provided unprecedented insights … inchree falls walk